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45 pages 1 hour read

Vivek Murthy

Together: The Healing Power of Human Connection in a Sometimes Lonely World

Nonfiction | Book | Adult | Published in 2020

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Part 1, Chapters 1-2Chapter Summaries & Analyses

Part 1: “Making Sense of Loneliness”

Part 1, Chapter 1 Summary: “Under Our Nose”

During Murthy’s early years as a doctor at Boston’s Brigham and Women’s Hospital, he noticed things about his patients that were not strictly medical—namely, their social isolation. While some patients were surrounded by family and friends, others went for weeks without visits or phone calls from the outside world. Some died alone. Murthy also noted that his patients yearned for companionship, which alerted him to the link between health and loneliness. James, a patient with diabetes, brought this connection into sharper focus. James quit his job as a baker and moved to an affluent enclave after winning the lottery. His health problems grew alongside his distance from other people. Patients like James made Murthy realize that social connection is integral to human health.

Murthy defines loneliness as a lack of social connection and an absence of closeness, trust, and affection from other people. He describes three types of loneliness: 1) Intimate loneliness, or the longing for a romantic partner and close friends; 2) Relational loneliness, or the desire for social companionship; and 3) Collective loneliness, or the hunger for a network of people with common interests and a shared sense of purpose. In contrast to isolation, which is an objective physical state, loneliness is a subjective feeling. Loneliness is involuntary and painful, unlike solitude, which is a voluntary, peaceful state of aloneness and a time for self-reflection and personal growth.

Millions of people around the world experience loneliness. Their loneliness makes them less apt to interact with others, triggering self-doubt and low self-esteem. Loneliness creates a self-perpetuating cycle that convinces people they are unworthy of love and dissuades them from pursuing the relationships they need most. Furthermore, shame and fear prevent lonely people from seeking help from friends, family, and doctors. Many turn to alcohol, drugs, food, and sex to numb their pain. Thus, loneliness not only impacts personal health and productivity, but also society. The impact of loneliness also includes premature death and a variety of health conditions, including diabetes, high blood pressure, stroke, dementia, depression, and obesity. Medical professionals now recognize the deleterious effects of loneliness on physical and mental health. Medicine and technology have their limits in treating loneliness. By contrast, human connection, compassion, and love are boundless.

Part 1, Chapter 2 Summary: “The Evolution of Loneliness”

Chapter 2 focuses on the evolutionary theory of loneliness. Murthy describes the public reception of his first article on loneliness before segueing to the work of Dr. John Cacioppo, who argued that the human need for connection is biologically and socially rooted in human evolution. According to Cacioppo, humans survived as a species not just because of their strength and speed, but also because they formed groups, exchanged information, and coordinated goals, skills that evolved from monkeys and apes. Evolutionary pressure led to more cooperation, making it possible to plan for the future and divide labor. Social groups provided the safety necessary for tribes to survive and multiply. They also spurred innovation and allowed knowledge to be passed down, which promoted a sense of belonging.

Dr. Steve Cole, a genomics researcher at the University of California, Los Angeles, studied the links between social connection and human health. Social connection decreases the body’s stress response, leaving people less anxious and feeling more secure. The body promotes social connection with feel-good hormones and neurotransmitters, such as dopamine, endorphins, and oxytocin. Studies of the human brain show that the medial prefrontal cortex lights up when people think about themselves. This activity, known as self-processing, helps shape identity. Activity in the medial prefrontal cortex accelerates during social interactions, revealing that humans engage in self-processing even when they socialize. In short, the brain is wired to seek connection, focus on others, and define itself in relation to others.

Humans are born with the capacity to bond with anyone and learn any language. This capacity ebbs over time, a process called “perceptual narrowing.” This process evolved to create a sense of belonging and protect clan members against enemies, and hypervigilance set in when individuals strayed from their groups. According to Cacioppo, this hypervigilance underlies loneliness. Humans respond to isolation as they did during hunter-gatherer times. Loneliness triggers hypervigilance, causing a surge in stress hormones, adrenaline, blood pressure, and blood sugar. These evolutionary responses to danger are harmful when they persist. They increase cardiovascular stress and inflammation, which damages blood vessels and tissues, thereby raising the risk of heart disease and other chronic conditions. Loneliness also impacts sleep, leaving people mentally and physically fatigued. The cure for loneliness is to have meaningful social connections, but hypervigilance gets in the way, as lonely people see social threats where none exist. Genes also play a role in chronic loneliness, as do past experiences, current circumstances, personality, and culture. Whatever the cause, the brain processes loneliness the same way it processes physical pain. This overlap helps explain why people experiencing the pain of loneliness are at risk for addiction. Loneliness is mentally and physically harmful. Conversely, connection has the potential to heal.

Part 1, Chapters 1-2 Analysis

In Chapters 1 and 2, Murthy introduces The Impact of Loneliness on Physical and Mental Health, arguing that social isolation triggers biological and social reactions rooted in human evolution and genetics and that loneliness is a pervasive global issue.

Murthy cites studies to support his claims about loneliness. In Chapter 2, for example, he discusses Cacioppo’s work on social connection, which posits that the human need to connect is biologically and socially rooted in human evolution. As Murthy observes, the evidence supporting Cacioppo’s theory stretches back 52 million years. In 2011, anthropologists at the University of Oxford discovered that the earliest monkeys and apes did not connect in pairs, as researchers previously believed, but in groups of both sexes. This happened as previously nocturnal primates started hunting during the day, which made them more visible to predators. Strength in numbers thus made social connection important, supporting the book’s theme Social Connections as an Antidote to Loneliness.

Murthy also uses statistics to support his arguments and establish the role of genetics in chronic loneliness. For example, he cites Cacioppo’s study of loneliness and genetics published in 2016 in Neuropsychopharmacology: “the tendency to feel lonely over a lifetime, rather than just occasionally due to circumstance, is between 14 and 27 percent heritable based on an analysis of common gene variants” (53). The scope of the study lends weight to the conclusions: Over 10,000 people aged 50 or older participated in the study.

Murthy also examines the pervasiveness of loneliness, emphasizing both its scope and the global scale of the issue. A 2018 report by the Henry J. Kaiser Family Foundation, for example, reveals that 22% of American adults are often or always lonely: “That’s well over fifty-five million people—far more than the number of adult cigarette smokers and nearly double the number of people who have diabetes” (26). Similarly, a 2018 AARP study validated by UCLA found that one in three adults in the US over the age of 45 is lonely, while one-fifth of respondents from a Cigna survey from the same year said they rarely or never feel close to people. Studies from other countries echo these findings, revealing that loneliness is a global problem:

Among middle-aged and elderly Canadians, nearly one-fifth of men and around a quarter of women said they feel lonely once a week or more. One-quarter of Australian adults reported being lonely as well. More than two hundred thousand seniors in the United Kingdom ‘meet up with or speak on the phone with their children, family and friends less often than once a week’;13 percent of Italian adults report having no one to ask for help; and in Japan, over 1 million adults meet the official government definition of social recluses, or hikikomori (26).

In addition to conveying the prevalence of loneliness worldwide, statistics support Murthy’s claims about its harmful effects on human health. For example, a 2009 study at Brigham Young University revealed that those with strong social connections are half as likely to die prematurely than those with week social connections. Thus, the impact of loneliness on lifespan is equal to smoking 15 cigarette per day. It also exceeds the risk associated with excessive alcohol consumption, obesity, and lack of exercise. A 2013 poll of American general practitioners reiterated the health risks of social isolation, with 75% reporting that they saw up to five patients each day for conditions driven primarily by loneliness. These statistics support Murthy’s argument about the negative impact of loneliness on health and the necessity of social contact. As he puts it, “Just as hunger and thirst are our body’s ways of telling us we need to eat and drink, loneliness is the natural signal that reminds us when we need to connect with other people” (27).

These chapters establish Murthy’s use of anecdotes to connect with and engage readers by highlighting both his authority, as a physician, and his vulnerability, as a person who has experienced loneliness. Chapter 1 opens with an account of his first day as a doctor at Brigham and Women’s Hospital. Murthy includes details that not only allow readers to visualize the moment, but also convey its importance: “I was wearing a pressed white coat and […] smiled at the security guards and passing staff. For them, this was just another day at a busy urban hospital, but for me, it was a day I’d remember for the rest of my life” (19). Chapter 2 also starts with an anecdote as Murthy describes the public reception of an article on loneliness he wrote for the Harvard Business Review. Murthy accepted an invitation to speak on the subject from an Iowa radio station, where listeners called in to share their experiences. Their openness prompted Murthy to reflect on his childhood experiences with loneliness as an immigrant: “[W]e didn’t have anyone who shared, much less understood, our culture or traditions […] It took me a long time to feel that I belonged here” (38). This anecdote not only generates empathy for the author—a key emotion for fostering connection—but also conveys the scope of the loneliness problem.

In addition to anecdotes, Murthy employs vivid diction. In Chapter 1, for example, he tells the story of a baker who quit his job and moved to an affluent enclave after winning the lottery. Murthy describes James’s new home as a “gilded cage” (23). Similarly, he describes solitude as “the space where we confront our demons” (25). This word choice serves to promote an engaging and accessible, rather than purely theoretical, tone.

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